Perfectly positioned between Downtown Charleston and Sullivan's Island, this beautifully appointed Lowcountry home in Brookgreen Meadows offers a rare and flexible floorplan featuring both a downstairs and upstairs primary suite. Set on a generous corner lot, 22 Pearl Avenue blends coastal charm and modern comfort with 4 bedrooms, 3.5 baths, and thoughtfully designed indoor and outdoor spaces ideal for both everyday living and entertaining. The home features a full-length Charleston-style piazza and an open-concept layout with soaring ceilings, wide-plank white oak flooring, and a bright dining area with double doors opening to the piazza. The kitchen is equipped with an oversized quartz island, hammered copper farmhouse sink, white shaker cabinetry, quartz countertops, tiled backsplash,and stainless steel appliances including a beverage cooler and five-burner gas range. Two primary suites--one on the main level and one upstairs--provide flexibility for guests or multi-generational living. The upstairs primary includes dual walk-in closets. Two additional bedrooms, each with walk-in closets, share a hall bath with dual vanity. Additional highlights include a spacious laundry room, custom closet shelving, detached storage building, and off-street parking. Outdoor living is enhanced by a large yard with mature trees and a private fire pit courtyard, perfect for entertaining. Located in the desirable Coleman Corridor, enjoy easy access to Alhambra Hall, Pitt Street Bridge, Shem Creek, shops, dining, and the Mount Pleasant Farmers Market. Zoned for Mount Pleasant Academy, Moultrie Middle, and Lucy Beckham High, and just minutes to Downtown Charleston and Sullivan's Island.